Charles DeLisi (USA)
Biological Universality: How an Understanding of Human Biology is Developed by In Vitro and In Silico Experiments
Regency Ballroom E, F, G, H

A6:

Organ Studies I: Liver and Drug Metabolism Esplanade A
CHAIRS: Vera Rogiers (Belgium) and Jose Castell (Spain)

SPEAKERS:
Major Phase I Biotransformation Pathways of Trichostatin A in Rat Hepatocytes and Rat and Human Liver Microsomes
Vera Rogiers (Belgium)

Drug Biotransformation by Human Hepatocytes: In Vitro/In Vivo Metabolism by Cells from the Same Donor
Jose Castell (Spain)

Hepatocytes Cultivated In Vitro as an Alternative for Testing of Substances with Potential Hepatoprotective Effect
Z. Cervinkova (Czech Republic)

A New Human Hepatoma Cell Line to Study Repeated Cell Toxicity
Françoise Paillard (France)

B1:

Enrichment, Science, and Animal Welfare Esplanade B
CHAIRS: Kathryn Bayne (USA) and Joe Garner (USA)

SPEAKERS:
Why Every Scientist Should Care About Animal Welfare: Abnormal Repetitive Behavior and Brain Function in Captive Animals
Joe Garner (USA)

Preparing Laboratory Beagles for Life as Working Dogs
Sarah Heath (UK)

Scientific Program Taming and Training of Pregnant Ewes and Newborn Lambs Before Experiment
David Mellor (New Zealand)

Refinement of Routine Procedures: Can Environmental Enrichment Reduce the Stress Response of Laboratory Mice?
M.K. Meijer (The Netherlands)

A Better Mouse Cage
G.F. Rivard (USA)

C6:

Issues in Animal Research Esplanade C
CHAIRS: Derek Fry (UK) and Ken Shapiro (USA)

SPEAKERS:
The Validity/Ethics Antinomy in Animal Research
Ken Shapiro (USA)

Can Studies of Invertebrates Help Us Formulate Policy on Which Species Should be Protected in Experiments?
Chris Sherwin (UK)

Expanding the Three R’s to Meet New Challenges in Humane Animal Experimentation
Catherine Schuppli (Canada)

Animal Experimentation and Ethics -- the CPCSEA Makes Waves in India
Sonya Ghosh (India)

Ethical Use of Experimental Animals
H. Gürtler (Demark)

D5:

Information Providers, Resources, Tools, and Databases Cabildo A
CHAIRS: Barbara Grune (Germany) and Lisa Libowitz (USA)

SPEAKERS:
New Sources for Alternative Methods on the Internet: The Objectives of Databases and Web Sites
Barbara Grune (Germany)

Proposal for International Recognition, Support, and Cooperation with the Internet Clearinghouse on the Three R’s (AltWeb)
Lisa Libowitz (USA)

Search Strategies on the Internet—General and Specific
Krys Bottrill (UK)

A Guide to Animal Research Databases on the Deep Web
Tim Allen (USA)

The ECVAM SIS Projects
Andrew Burke (Italy) and Annett Roi (Italy)

E3:

Validation and Implementation of Alternative Methods for Identifying Endocrine Disrupters and Reproductive Toxicants Cabildo B
CHAIRS: Gary Timm (USA) and Tohru Inoue (Japan)

SPEAKERS:
Practical Approaches to Testing and Validation for Possible Endocrine Disruptors with Respect to a Mechanism of Action
Tohru Inoue (Japan)

An Alternative Strategy for the Assessment of Chemicals for Edocrine Disrupting Effects
T.K. Seidle, G. Langley, and R.W. Combes

The Environmental Protection Agency’s (EPA’s) Endocrine Disrupter Screening Program: Perspectives and Status
Gary Timm (USA)

Candidate Chemicals for Validation of In Vitro Estrogen and Androgen Receptor Binding and Transcriptional Activation Assays
Christina Inhof (USA)

Comparative Performance of Estrogen Receptor (ER) Binding and Transcriptional Activation Assays for Use as In Vitro Endocrine Disrupter Screening Methods
Barbara Shane (USA)

Ideology Masquerading as Science: The Case of Endocrine Disrupter Testing Programs
Troy Seidle (Canada)

W-C3:

Reducing the Use of Dogs and Other Non-Rodent Species in Safety Testing Cabildo C
MODERATORS: Horst Spielmann (Germany) and Barry Phillips (UK)

SPEAKERS:
The SET Study on the Use of Dogs as Second Species in Regulatory Testing of Pesticides, Part II: Subacute, Subchronic, and Chronic Studies in the Dog
Horst Spielmann (Germany)

An Approach to Minimize Dog Use in Regulatory Toxicology: Production of a Best Practice Guide to Study Design
Barry Phillips (UK)

Justification of the Non-Rodent Species Used in Pharmaceutical Toxicology
Christer Saffholm (UK) and David Smith (UK)

W-C4:

Practical Assessment of Harms and Benefits for Ethics Committees Esplanade A
MODERATORS: Tjard de Cock Buning (The Netherlands) and David Mellor (New Zealand)

SPEAKERS:
Comprehensive Assessment of Experimental Harms David Mellor (New Zealand)

PCP-C1:

Is Animal Research Necessary in the 21st Century? Esplanade B
Moderator: Jon Richmond (UK)

SPEAKERS:
Ray Greek (USA) and Michael Festing (UK)

W-D4:

Mechanics for Developing Software: New Projects and Training Programs Esplanade C
MODERATORS: Martha Rooks (USA) and H. van Wilgenburg (The Netherlands)

SPEAKERS:
Web-based Training: Design, Implementation, and Challenges
Martha Rooks (USA)

Experimental Design: Computer Simulation for Improving the Precision of an Experiment
H. van Wilgenburg (The Netherlands)

WE6:

Endocrine Disrupter Issues and Testing: A Discussion Cabildo B
MODERATORS: Errol Zeiger (USA) and John McLachlan (USA)

WE7:

Quality Control Issues in Test Kit Production Cabildo C
MODERATORS: Amy Rispin (USA), Foster Jordan (USA), and John Harbell (USA)

PCP-E1:

Are Animal Tests Inherently Valid? Poydras A/B
Moderator: Leon Bruner (USA)

SPEAKERS:
Michael Balls (UK), TBA (USA)

A4:

Vaccines and Biologicals: Application of the Three R’s Esplanade A
CHAIRS: Coenraad Hendriksen (The Netherlands) and Klaus Cussler (Germany)

SPEAKERS:
ECVAM’s Contributions to the Implementation of the Three R’s in the Quality Control of Biologicals
Marlies Halder (Italy)

Biological Standardization: A Coordinated European Program for the Reduction of Animal Testing
Jean-Marc Spieser (France)

Possibilities and Problems of Implementing Three R’s Alternatives in Developing Countries
José Luis DiFabio (USA)

Development of Alternative Lot Release Tests for Vaccine Products
Robin Levis (USA)

A New Approach in the Quality Control Testing of Inactivated Bacterial Vaccines
Marlies Leenaars (The Netherlands)

Results and Recommendations of an ECVAM Workshop on Alternatives in Rabies Vaccine Quality Control
Lukas Bruckner (Switzerland)

Serological Methods for Potency Testing of Tetanus Toxoid Vaccines for Human Use
Coenraad Hendriksen (The Netherlands) and Randi Winsnes (Norway)

In Vitro Assays for Biologicals Containing Leptospira interrogans serovars canicola, grippotyphosa, icterohaemorrhagiae, and pomona
Lawrence Elsken (USA)

B2:

Evaluation Techniques for Animal Well-Being Esplanade B
CHAIRS: Vera Baumans (Sweden) and David Mellor (New Zealand)

SPEAKERS:
Preference Tests and Consumer Demand Studies: Advantages and Limitations in Assessing Animal Welfare
Chris Sherwin (UK)

Methods for Evaluation of Laboratory Animal Well-Being
Vera Baumans (Sweden)

Non-invasive Stress Assessment in the Laboratory Rat
Georgia Mason (UK)

Refining Husbandry and Management of Large Primates
Sara Wolfensohn (UK)

Refinement of Gerbil Housing and Husbandry in the Laboratory
Eva Waiblinger (Switzerland)

Scientific Program The Wild Behaviors of Laboratory Rats (www.RATLIFE.org)
Manuel Berdoy (UK)

C3:

Policy Aspects of Chemicals Testing Initiatives and Alternatives Esplanade C
CHAIRS: Phil Sayre (USA) and Michael Balls (UK)

SPEAKERS:
HPV in the USA
Phil Sayre (USA)

The U.S. High-Production Volume Program: An Animal Protection Perspective
TBA (USA)

EU Chemicals Testing Initiative
Gerald Vollmer (Italy)

The New EU Chemicals Policy: Challenges and Chances for Free Test Methods
Ursula G. Sauer (Germany)

D3:

Three R’s Education for Those Involved in Animal-based Research Cabildo A
CHAIRS: Nicole Duffee (USA) and Bert van Zutphen (The Netherlands)

SPEAKERS:
AALAS Campus and ResearchTraining.Org—Two Online Learning Systems for Laboratory Animal Technicians and Researchers
Nicole Duffee (USA)

European Science Foundation (ESF) Endorses the Three R’s and the Education of Scientists on Laboratory Animal Science
L.F.M. van Zutphen (The Netherlands)

Developing Ethics Training for Laboratory Animal Users
Maggy Jennings (UK)

Policy on Education of Individuals Involved in Animal Experiments or Other Scientific Procedures with Animals in Germany
Klaus Nebendahl (The Netherlands)

Incorporating Animal Alternatives in a Training Program in Laboratory Animal Care and Use
Sally Walshaw (USA)

E7:

Skin and Phototoxicity Cabildo B
CHAIRS: Manfred Liebsch (Germany) and Roland Roguet (France)

SPEAKERS:
Update on the Validation and Regulatory Acceptance of Alternative Tests for Skin Corrosion and Irritation
Julia Fentem (UK)

Scientific Program Putting In Vitro Phototoxicity Testing into Practice: The Impact of International Commenting on a Scientifically Validated Method
Manfried Liebsch (Germany)

In Vitro Approach to Determine the Bio-availability of Topically Applied Cationic Hair Dyes
Winfried Steiling (Germany)

Comet Assay on EPISKIN, an In Vitro Reconstructed Skin Model: A New Tool for the Evaluation of (Photo) Genotoxic Potential
J.R. Meunier (France)

In Vivo and In Vitro Phototoxicity Assay Assessed with Various Fragrances
C.J. Nam (Korea)

W-B1:

Refinement/Reduction Through Design of the Experiment Cabildo C
MODERATORS: Michael Festing (UK) and Derek Fry (UK)

SPEAKERS:
Pilot Investigation of the Use of General Anesthesia to Refine the Statutory Mouse Bioassay for Paralytic Shellfish Poison
N. Dennison (UK)

Refinement and Reduction Through the Control of Variation
Michael F.W. Festing (UK)

Margaret Rose (Australia)
The Impact of Pain and Distress on the Outcome of Research: Why Animal Welfare and Good Science Go Together