Paul de Greeve (The Netherlands)
Trends in the Use of Animals and Alternatives Across the World
Regency Ballroom E, F, G, H

A1:

The Acquisition and Use of Human Cells in Research and Testing Esplanade A
CHAIRS: Robert Combes (UK) and Jan van der Valk (The Netherlands)

SPEAKERS:
The Use of Human Cells in Biomedical Research and Testing
Robert Combes (UK)

Dutch Guidelines for the Use of Human Tissue in Research
Jan van der Valk (The Netherlands)

Human Cells and Tissues for Research: Setting up the European Network of Research Tissue Banks
Dariusz Sladowski (Poland)

The Establishment of the UK Human Tissue Bank
Samantha Orr (UK)

B4:

Animal Welfare: Guidelines and Beyond Esplanade B
CHAIRS: Jean-Marc Spieser (France) and David Anderson (UK)

SPEAKERS:
Three R Alternatives Provided by the European Pharmacopoeia—Are They Used in Practice?
Klaus Cussler (Germany)

Revision of Council of Europe Convention ETS 123 Guidelines for the Accommodation and Care of Animals Used for Experimental and Other Scientific Purposes
David Anderson (UK)

The Revision of European Housing Guidelines for Laboratory Animals: Expectations from the Point of View of Animal Welfare
Ursula G. Sauer (Germany)

The Environmental Enrichment Committee
K.L. Stewart (USA)

Refinement by an Adequate Pain Management Protocol: Report of the Working Group of the German Society of Laboratory Animal Science (GV-SOLAS)
M. Sager (Germany)

C1:

Animal Numbers and Trends from Around the World Esplanade C
CHAIRS: Paul de Greeve (The Netherlands) and Clement Gauthier (Canada)

SPEAKERS:
Overview and Analysis of Animal Use in North America
Clement Gauthier (Canada)

Animal Use in the United Kingdom
Jon Richmond (UK)

Animal Use Statistics: The New Zealand and Australian Experience and Perspective
David Bayvel (New Zealand)

Transition of Animal Numbers Used for Experiments and Recent Trends in Japan
Yukihisa Matsuda (Japan)

D1:

Transforming Middle and High School Education with Animal Alternatives Cabildo A
CHAIRS: Lynette Hart (USA) and Steve Zawistowski (USA)

SPEAKERS:
Biology Teachers’ Attitudes to Dissection and Alternatives
Lesley King (USA)

Uses of Animals and Alternatives in Pre-College Education of the United States: Needs for Leadership and Guidelines
Lynette Hart (USA)

JSAAE Activities in Alternatives to Animal Experimentation for Undergraduate Schools: Forum for Primary and Secondary Schools
Tsutomu Miki Kurosawa (Japan)

Activities in German-Speaking Countries (Germany, Austria, Switzerland) to Transform School Education with the Objective of Increasing Student Awareness of Animal Welfare Issues
Joerg Luy (Germany)

The Use of Animals in National High School Student Science Fair Projects
Crystal Miller Spiegel (USA)

E1:

Validation of Alternative Test Methods: Recent Progress and New Initiatives Cabildo B
CHAIRS: William Stokes (USA) and Julia Fentem (UK)

SPEAKERS:
The Principles of Validation and the ECVAM Validation Process
Andrew Worth (Italy)

The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM): Recent Progress in the Evaluation of New Toxicological Testing Methods
William Stokes (USA)

The ZEBET Funding Program for the Development of Alternatives to Testing in Animals
Horst Spielmann (Germany)

The New Look of the Test Method Validation
Hiroshi Ono (Japan)

The Third FRAME Toxicity Committee: Working Toward Greater Implementation of Alternatives in Toxicity Testing
Robert Combes (UK)

W-A5:

Statistical Reduction Strategies and Using In Vitro Data as Part of a Reduction Strategy Cabildo C
MODERATORS: Michael Festing (UK) and Raj Chhabra (USA)

SPEAKERS:
Good Experimental Design and Statistics Can Save Animals, but How can it be Promoted?
Michael Festing (UK)

Evaluation of Some In Vitro Tests to Reduce and Replace the Sub-acute Animal Toxicity Tests
Raj Chhabra (USA)

W-B3:

Assessing and Managing Pain and Distress for Ethics Committees Poydras A/B
MODERATORS: Alicia Karas (USA) and Paul Flecknell (UK)

SPEAKERS:
Physiological and Behavioral Assessment of Pain in Ruminants
David Mellor (New Zealand)

Genomic Approaches to Pain Assessment and Alleviation
Norman C. Peterson (USA)

W-A1:

Calf Serum Replacement in Cell Cultures Esplanade A
MODERATORS: Franz Gruber (Switzerland) and Vera Baumans (Sweden)

W-C1:

Transgenic Animal Issues Esplanade B
MODERATORS: Victoria Hampshire (USA) and Jean Fleming (New Zealand)

W-C5:

Xenotransplantation Esplanade C
MODERATORS: John McArdle (USA), Louisa Chapman (USA), and Jon Richmond (UK)

W-D1:

Searching for Information: A Critical Discussion Cabildo A
MODERATORS: Stuart Nelson (USA) and Krys Bottrill (UK)

SPEAKERS:
Improving MEDLINE Coverage of Alternatives to Animal Use Stuart Nelson (USA)

Search Filters, a New Tool for Alternatives: Locating Mouse Strains as Disease Models
Mary Wood (USA)

PCP-D1:

Are Animals Necessary in Biological Education? Cabildo B
Moderator: Roman Kolar (Germany)

W-E1:

Outcome of OECD Conference on Validation and Regulatory Acceptance of New and Updated Test Methods in Hazard Assessment Poydras A/B
MODERATORS: Herman Koëter (France) and David Blakey (Canada)

A2:

Immortalization Versus Redifferentiation of Cell Lines Esplanade A
CHAIRS: Jose Castell (Spain) and William Smith (USA)

SPEAKERS:
The Use of Cultured Human Keratinocytes in Dermatological Investigations
William Smith (USA)

Can Hepatoma Cell Lines Be Redifferentiated to be Useful in Drug Metabolism Studies?
Jose Castell (Spain)

Scientific Program Transfection of Hybridoma Cell Lines with an Anti-apoptosis Gene Increases Viability and In Vitro Monoclonal Antibody Production
Norman Peterson (USA)

Cell Signalling Trichostatin A-Treated Primary Hepatocyte Cultures: Effect on Proliferation and Apoptosis
Vera Rogiers (Belgium)

Use of Genetically Engineered PC12 Cell Lines for Detecting Subchronic p53-Mediated Cell Death
Chantra Eskes (Italy)

B5:

Novel Methods for Science—Welfare Concerns Esplanade B
CHAIRS: Christian Cook (New Zealand) and James Kirkwood (UK)

SPEAKERS:
Reducing the Invasiveness of Obtaining Blood-borne Measures in Animals
Christian Cook (New Zealand)

Use and Pitfalls of Allometry: An Essential Tool in Ethical Decisions About Validity of Extrapolating Between Species
James Kirkwood (UK)

Non-invasive Imaging by Echocardiography to Study Mechanisms of Mitochondrial Cardiac Toxicity
K. Gabrielson (USA)

Better Data from Fewer Mice: High-Throughput, Noninvasive Physiological Assays in Conscious Mice Are Accelerating Functional Genomics
T.G. Hampton (USA)

Refinement and Reduction of Animal Use by Application of Whole Animal Cell and Molecular Imaging Methods
Pam Contag (USA)

Suitability of Temperature-Sensitive Transponders to Measure Body Temperature During Animal Experiments Required for Regulatory Tests
Klaus Cussler (Germany)

C2:

Ethical Issues in Primate Research Esplanade C
Chairs: Ursula G. Sauer (Germany) and Kathryn Bayne (USA)

SPEAKERS:
The Moral Standing of Non-Human Primates: Why They Merit Special Consideration
Ursula G. Sauer (Germany)

A Demographic Analysis of Primate Research in the USA
Kathleen Conlee (USA)

Ethical and Welfare Implications of the Acquisition and Transport of Non-Human Primates for Use in Research and Testing
Maggy Jennings (UK)

The Welfare of Non-Human Primates in Research in the EU—An Update
David Morton (UK)

The Great Ape Project: Legislating for the Control of the Use of Non-Human Hominids in Research, Testing, and Teaching—Animal Welfare Act 1999 (New Zealand)
Neil Wells (New Zealand)

W-E5:

Evaluating Safety Tests: Some Recent Experiences and Analyses Cabildo A
MODERATORS: Leon H. Bruner (USA), Rodger Curren (USA), and Elke Genschow (Germany)

SPEAKERS:
Assessing the Performance of Toxicity Tests in Validation Studies
Leon H. Bruner (USA)

Using an "Outcome-based" Approach to Describe the Performance of Toxicity Tests that Provide Only Dichotomous Data
Rodger Curren (USA)

Considering the Test Performance for Trichotomous Data Using Linear Discriminant Analysis—A Case Study
Elke Genschow (Germany)

E2:

Regulatory Acceptance of Alternative Methods: Recent Progress and New Initiatives Cabildo B
CHAIRS: Len Leonard Schechtman (USA) and Julia Fentem (UK)

SPEAKERS:
The Regulatory Acceptance of Alternatives in the EU
Vicky Warbrick (UK)

FDA Regulatory Role in the ICCVAM Process
Len Leonard Schechtman (USA)

Scientific Program Validation and Regulatory Acceptance of Alternative Methods—Regulatory Acceptance in Japan
Yasuo Ohno (Japan)

Validation in Practice: Suiting the Action to the Word
Herman Koëter (France)

W-E2:

Training for the Implementation of Alternative Test Methods Cabildo C
MODERATORS: Marlies Halder (Italy) and Denise Sailstad (USA)

W-E3:

Validation of (Q)SAR and Other Computational Prediction Models Poydras A/B
MODERATORS: Andrew Worth (Italy) and Mark Cronin (UK)

Ray Tennant (USA)
Toxicogenomics—What Is It, and What Are the Implications for Alternatives?